While it is usually believed that the extent of hair loss is the best predictor of the severity of distress the patients will experience, for some populations, it is more a question of location than extent of hair loss determining the psychological effects. A higher prevalence of depression, anxiety, poor self-esteem and body image, social phobias, and paranoid disorders have been reported, resulting in a reduced quality of life. This report highlights the beneficial effects of the JAK inhibitors, especially in populations where the hair has a special importance due to cultural and religious backgrounds.Īlopecia areata can lead to significant psychological and social sequelae in many patients. The Janus kinase (JAK) inhibitors have recently emerged as an effective treatment modality in AA, including the more severe forms, such as AT or AU. The beard has a special significance for ultraorthodox Jews, and loss of the beard hair can have marked social and psychological consequences in AA patients. The patient was treated with ruxolitinib, 20 mg twice daily, resulting in complete growth of the beard after 4 months of treatment.
Previous treatments with intralesional and systemic corticosteroids had only partial and temporary effects. We report on a 33-year-old ultraorthodox Jewish man with an 11-year history of AA that resulted in complete loss of the scalp and body hair 7 years ago.
While most alopecia areata (AA) cases resolve spontaneously, the more severe types of AA, alopecia totalis (AT) and alopecia universalis (AU), can be highly resistant to therapy.
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